Ph.D. Seoul National University, School of Pharmacy
2006. 2
M.S. Seoul National University, School of Pharmacy
2004. 2
B.S. Seoul National University, School of Pharmacy
2017.7-2020.8
Assistant Research Scientist, University of California-San Francisco
2013. 7-2017.6
Postdoctoral Researcher, University of California-San Francisco
2011. 9-2013. 6
Postdoctoral Researcher, Research Institute of Pharmaceutical Sciences, Seoul National University
논문1
Chen, X.;Lee, S.; Zhang, T.; Duan, T.;Pasricha, N. D.; Schallhorn, J. M.; Levin, M. H.; Koprivica, V.; Verkman, A. S.
논문2
Lee, S.; Cil, Onur; Haggie, P. M.; Verkman, A. S. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J. Med. Chem. 2019, 62, 8330-8337.
논문3
Haggie, P. M.; Cil, O.; Lee, S.; Tan, T. A.; Rivera, A. A.; Phuan, P. W.; Verkman, A. S. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight 2019, 3, 14.
논문4
Jin, B.-J.; Lee, S.; Verkman, A. S. Hollow Micropillar Allay Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Anal. Chem. 2018, 90, 7675-7681.
논문5
Lee, S.; Cil, O.; Diez-Cecili, E.; Anderson, M. O.; Verkman, A. S. Nanomolar potency inhibitor of UT-A1. J. Med.Chem. 2018, 61, 3209-3217.
논문6
Truong, E.C.; Phuan, P.W.; Reggie A.L.; Fererra, L.; Galietta L.J.V.; Levy, S.E.; Moises, A.C.; Cil, O.; Diez-Cecilia, E.; Lee, S.; Verkman A.S.; Anderson M.O. “Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A).” J. Med. Chem. 2017, 60, 4626–4635.
논문7
Son, J.-H.; Zhu, J. S.; Phuan, P.-W.; Cil, O.; Teuthorn, A. P.; Ku, C. K.; Lee, S.; Verkman, A. S.; Kurth, M. J. “High-potency phenylquinoxalinone cystic fibrosis transmembrane conductance regulator (CFTR) activators.” J. Med.Chem., 2017, 60, 2401-2410.
논문8
Lee, S.; Phuan, P.-W.; Felix, C. M.; Tan, J.; Levin, M. H.; Verkman, A. S. “Nanomolar-potency aminophenyl-1,3,5-triazine Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride channel activators for pro-secretory therapy of dry eye diseases.” J. Med.Chem., 2017, 60, 1210-1218.
논문9
Cil, O.; Phuan, P.-W.; Gillespie, A. M.; Lee, S.; Tradtrantip, L.; Yin J.; Tse, M.; Zachos, N. C.; Lin, R.; Donowitz, M.; Verkman, A. S. “Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for anti-secretory therapy of diarrheas caused by bacterial enterotoxins.” FASEB J. 2017, 31, 751-760.
논문10
Cil, O.; Phuan, P.-W.; Lee, S.; Tan, J.; Haggie, P. M.; Levin, M. H.; Sun, L.; Thiagarajah, J. R.; Ma, T.; Verkman, A. S.” CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation.” Cell.Mol. Gastroenterol. Hepatol., 2016, 2, 317-312.
논문11
Esteva-Font, C.; Jin, B.-J.; Lee, S.; Phuan, P.-W.; Anderson, M. O.; Verkman, A. S. “Experimental evaluation of proposed small-molecule inhibitors of water channel aquaporin-1.” Mol. Pharmalcol. 2016, 89, 686-693.
논문12
Lee, S.; Esteva-Font, C.; Phuan, P.-W.; Anderson, M. O.; Verkman, A. S. “Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors” MedChemComm, 2015, 6, 1278-1284.
논문13
Esteva-Font, C.; Phuan, P.-W.; Lee, S.; Su, T.; Anderson, M. O.; Verkman, A. S. “Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters” Biochimica et Biophysica Acta (BBA)-Biomembranes, 2015, 1848, 1075-1080.
논문14
Cil, O.; Esteva-Font, C.; Tas, S. T.; Su, T.; Lee, S.; Anderson, M. O.; Ertunc, M.; Verkman, A. S. “Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats” Kidney International, 2015, 88, 311-320.
논문15
Kim, K.; Maharjan, S.; Lim, C.; Kim, N.-J.; Agarwal, V.; Han, Y.-T.; Lee, S.; An, H.; Yun, H. Choi, H.-J.; Kwon, Y. G.; Suh, Y.-G. “Glucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C17-side chain” Eur.J.Med.Chem., 2014, 75, 184-194.
논문16
Esteva-Font, C.; Cil, O.; Phuan, P.-W.; Su, T.; Lee, S.; Anderson, M. O.; Verkman, A. S. “Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A selective urea transport inhibitors” FASEB J., 2014, 28, 3878-3890.
논문17
Seo, H.; Yun, H.; Lee, S.; Jang, J.; Han, Y. T.; Kim, D.-D.; Lee, J.; Suh, Y.-G. “Stereoselective synthesis of 7-epi-Incarvilline” Org. Lett., 2013, 15, 531-533.
논문18
Chang, D.-J.; An, H.; Kim, K.-S.; Kim, H. H.; Jung, J.; Lee, J. M.; Kim,N.-J.; Han, Y. T.; Yun, H.; Lee, S.; Lee, G.; Lee, S.; Lee, J. S.; Cha, J.-H.; Park, J.-H.; Park, J. W.; Lee, S.-C.; Kim, S. G.; Kim, J. H.; Lee, H.-Y.; Kim, K.-W.; Suh, Y.-G. “Design, Synthesis and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis” J. Med. Chem., 2012, 55, 10863-10884.
논문19
Sim, J.; Yun, H.; Jung, J.-W.; Lee, S.; Kim, N.-J.; Suh, Y.-G. “Achiral auxiliary-assisted chiral transfer via microwave-accelerated aza-Claisen rearrangement: a short synthesis of (+)-1-hydroxyquinolizidinone” Tetrahedron Lett. 2012, 53, 4813-4815.
논문20
Chang, D.-J.; Lee, S.; Jang, J.; Kim, S.-O.; Kim, W.-J.; Suh, Y.-G. “Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties” Bioorg. Med. Chem. Lett. 2012, 22, 6750-6755.
논문21
Yun, H.; Kim, J.; Sim, J.; Lee, S.; Han, Y. T.; Chang, D.-J.; Kim, D.-D.; Suh, Y.-G. “Asymmetric Syntheses of 1-Deoxy-6,8a-di-epi-castanospermine and 1-Deoxy-6-epi-castanospermine” J. Org. Chem. 2012, 77, 5389−5393.
논문22
Han, Y. T.; Choi, G.-I.; Son, D.; Kim, N.-J.; Yun, H.; Lee, S.; Chang, D.-J.; Hong, H.-S.; Kim, H.; Ha, H.-J.; Kim, Y.-H.; Park, H.-J.; Lee, J.; Suh, Y.-G. “Ligand-Based Design, Synthesis, and Biological Evaluation of 2- Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors” J. Med. Chem. 2012, 55, 9120-9135.
논문23
Lee, S.; Marharjan, S.; Jung, J.-W.; Kim, N.-J.; Kim, K.; Han, Y. T.; Lim, C.; Choi, H.-J.; Kwon, Y.-G.; Suh, Y.-G. “Novel Human Umbilical Vein Endothelial Cells (HUVEC)-Apoptosis Inhibitory Phytosterol Analogues: Insight into Their Structure-Activity Relationships” Arch. Pharm. Res.2012, 35, 455-460.
논문24
Lee, S.; Paek, S.-M.; Yun, H.; Kim, N.-J.; Suh, Y.-G. “Enantioselective Total Synthesis of a Natural Iridoid” Org. Lett. 2011, 13, 3344-3347.
논문25
Maharjan, S.; Lee, S.; Agrawal, V.; Choi, H.-J.; Maeng, Y.-S.; Kim, K.; Kim, N.-J.; Suh, Y.-G.; Kwon, Y.-G. “Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy” Eur. J. Pharmacol. 2011, 657, 35-40.
논문26
Han, Y. T.; Kim, N.-J.; Jung, J.-W.; Yun, H.; Lee, S.; Suh, Y.-G. “A Versatile Synthetic Approach to Grandisol Monoterpene Pheromone” Arch. Pharm. Res. 2011, 34, 1437-1442.
논문27
Lee, S.; Maharjan, S.; Kim, K.; Kim, N.-J.; Choi, H.-J.; Kwon, Y.-G.; Suh, Y.-G. “Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1” Bioorg. Med. Chem. Lett. 2010, 20, 7102-7105.
논문28
Han, Y. T.; Paek, S.-M.; Lee, S.; Jung, J.-W.; Jung, J.-K.; Seo, S.-Y.; Lee, J.; Suh, Y.-G. “Thermodynamic equilibration in Pd(0)-catalyzed interconversion of highly constrained [2.1.2] bicyclic lactones: its mechanistic investigation” Tetrahedron Lett. 2010, 51, 2697-2699.
논문29
Paek, S.-M.; Yun, H.; Kim, N.-J.; Jung, J.-W.; Chang, D.-J.; Lee, S.; Yoo, J.; Park, H.-J.; Suh, Y.-G. “Concise Syntheses of (+)-Macrosphelides A and B: Studies on the Macro-Ring Closure Strategy” J. Org. Chem. 2009, 74, 554-561.