Ph.D. College of Pharmacy, Seoul National University
2007. 02.
B.S. College of Pharmacy, Seoul National University
2021. 06. - 2024. 02.
Assistant Research Professor, Seoul National University
2020. 03. - 2021. 05.
Postdoctoral Associate, Seoul National University
2016. 01. - 2019. 12.
Postdoctoral Associate, University of Pittsburgh
2014. 09. - 2015. 12.
Postdoctoral Fellow, Seoul National University
논문 1
Kim SR*, Park JW*, Choi YJ, Sonn SK, Oh GT, Lee BH, Chang TS. Mitochondrial H2O2 is a central mediator of diclofenac-induced hepatocellular injury. Antioxidants. 2023 Dec;13(1):17.
논문 2
Choi YJ, Yun SH, Yu J, Mun Y, Lee W, Park CJ, Han BW, Lee BH. Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1. Mol Metab. 2023 Oct;76:101784.
논문 3
Lee W*, Mun Y*, Lee, KY, Park JM, Chang TS, Choi, YJ§, Lee BH§. Mefenamic acid-upregulated Nrf2/SQSTM1 protects hepatocytes against oxidative stress-induced cell damage. Toxics. 2023 Sep;11(9):735.
논문 4
Choi YJ, Yang HS, Zhang Y, Lee W, Yun SH, Nam YA, Lee G, Jung BH, Chang TS, Lee K, Lee BH. Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver. Ecotoxicol Environ Saf. 2022 Dec;247:114213.
논문 5
Choi YJ, Lee G, Yun SH, Lee W, Yu J, Kim SK, Lee BH. The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation. Amino Acids. 2022 May;54(5):823-834. 7
논문 6
Lee W, Kim HY, Choi YJ, Jung SH, Nam YA, Zhang Y, Yun SH, Chang TS, Lee BH. SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation. Theranostics. 2022 Feb;12(5): 2351–2369.
논문 7
Jung SH, Lee W, Park SH, Lee KY, Choi YJ, Choi S, Kang D, Kim S, Chang TS, Hong SS, Lee, BH. Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity. Redox Biol. 2020 Oct;37:101751.
논문 8
Silva Barbosa AC, Zhou D, Xie Y, Choi YJ, Tung HC, Chen X, Xu M, Gibbs RB, Poloyac SM, Liu S, Yu Y, Luo J, Liu Y, Xie W. Inhibition of estrogen sulfotransferase (SULT1E1/EST) ameliorates ischemic acute kidney injury in mice. J Am Soc Nephrol. 2020 Jul;31(7):1496-1508.
논문 9
Sim WC, Lee W, Sim H, Lee KY, Jung SH, Choi YJ, Kim HY, Kang KW, Lee JY, Choi YJ, Kim SK, Jun DW, Kim W, Lee BH. Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease. Metabolism. 2020 Jan;102:154000.
논문 10
Sim WC, Kim DG, Lee W, Sim H, Choi YJ, Lee BH. Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. Cell Biol Toxicol. 2019 Oct;35(5):457-470.
논문 11
Lee KY, Lee W, Jung SH, Park J, Sim H, Choi YJ, Park YJ, Chung Y, Lee BH. Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice. Biochem Pharmacol. 2019 Aug;166:46-55.
논문 12
Lee W, Koo HR, Choi YJ, Choi JG, Oh MS, Jin X, Choo M, Park S, Jeong YS, Chung SJ, Lee BH. Z-ligustilide and n-butylidenephthalide isolated from the aerial parts of Angelica tenuissima inhibit lipid accumulation in vitro and in vivo. Planta Med. 2019 Jul;85(9-10):719-728.
논문 13
Krzysiak TC, Thomas L, Choi YJ, Auclair S, Qian Y, Luan S, Krasnow SM, Thomas LL, Koharudin LMI, Benos PV, Marks DL, Gronenborn AM, Thomas G. An insulin-responsive sensor in the SIRT1 disordered region binds DBC1 and PACS-2 to control enzyme activity. Mol Cell. 2018 Dec;72(6):985-998.
논문 14
Choi YJ, Zhou D, Barbosa ACS, Niu Y, Guan X, Xu M, Ren S, Nolin TD, Liu Y, Xie W. Activation of constitutive androstane receptor ameliorates renal ischemia-reperfusion-induced kidney and liver injury. Mol Pharmacol. 2018 Mar;93(3):239-250.
논문 15
Choi YJ, Lee KY, Jung SH, Kim HS, Shim G, Kim MG, Oh YK, Oh SH, Jun DW, Lee BH. Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. Toxicol Appl Pharmacol. 2017 Feb;316:74-82.
논문 16
Sim WC, Han I, Lee W, Choi YJ, Lee KY, Kim DG, Jung SH, Oh SH, Lee BH. Inhibition of homocysteine-induced endoplasmic reticulum stress and endothelial cell damage by l-serine and glycine. Toxicol In Vitro. 2016 Aug;34:138-145.
논문 17
Sim WC, Kim DG, Lee KJ, Choi YJ, Choi YJ, Shin KJ, Jun DW, Park SJ, Park HJ, Kim J, Oh WK, Lee BH. Cinnamamides, novel liver X receptor antagonists that inhibit ligand-induced lipogenesis and fatty liver. J Pharmacol Exp Ther. 2015 Dec;355(3):362-369.
논문 18
Choi YJ, Lee CH, Lee KY, Jung SH, Lee BH. Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice. Toxicol Sci. 2015 Jun;145(2):273-282.
논문 19
Choi YJ, Yoon Y, Lee KY, Kang YP, Lim DK, Kwon SW, Kang KW, Lee SM, Lee BH. Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis. Toxicol Sci. 2015 Apr;144(2):307-317.
논문 20
Sim WC, Yin HQ, Choi HS, Choi YJ, Kwak HC, Kim SK, Lee BH. L-serine supplementation attenuates alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats. J Nutr. 2015 Feb;145(2):260-267.
논문 21
Choi YJ, Suh HR, Yoon Y, Lee KJ, Kim DG, Kim S, Lee BH. Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase. Arch Pharm Res. 2014 Sep;37(9):1169-1176.
논문 22
Sim WC, Park S, Lee KY, Je YT, Yin HQ, Choi YJ, Sung SH, Park SJ, Park HJ, Shin KJ, Lee BH. LXR-α antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver. Biochem Pharmacol. 2014 Aug;90(4):414-424.
논문 23
Choi YJ, Yoon Y, Lee KY, Hien TT, Kang KW, Kim KC, Lee J, Lee MY, Lee SM, Kang DH, Lee BH. Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. FASEB J. 2014 Jul;28(7):3197-3204.
논문 24
Lee KY, Oh S, Choi YJ, Oh SH, Yang YS, Yang MJ, Lee K, Lee BH. Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats. Toxicol Sci. 2013 Nov;136(1):193-204.
논문 25
Choi YJ, Sim WC, Choi HK, Lee SH, Lee BH. α-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway. Food Chem Toxicol. 2013 May;55:129-136.
논문 26
Park S, Choi YJ, Lee BH. In vitro validation of drug-induced phospholipidosis. J Toxicol Sci. 2012 Apr;37(2):261-267.
논문 27
Choi YJ, Yoon Y, Choi HS, Park S, Oh S, Jeong SM, Suh HR, Lee BH. Effects of medicinal herb extracts and their components on steatogenic hepatotoxicity in Sk-hep1 cells. Toxicol Res. 2011 Dec;27(4):211-216.
논문 28
Choi YJ, Yin HQ, Suh HR, Lee YJ, Park SR, Lee BH. Involvement of E2F1 transcriptional activity in cadmium-induced cell-cycle arrest at G1 in human lung fibroblasts. Environ Mol Mutagen. 2011 Mar;52(2):145-152.
논문 29
Lee HY*, Choi YJ*, Jung EJ, Yin HQ, Kwon JT, Kim JE, Im HT, Cho MH, Kim JH, Kim HY, Lee BH. Genomics-based screening of differentially expressed genes in the brains of mice exposed to silver nanoparticles via inhalation. J Nanopart Res. 2010 June;12(5):1567-1578.
논문 30
Choi YJ, Yin HQ, Park EJ, Park K, Kim DS, Lee BH. Gene expression analysis of so called asian dust extracts in human acute myeloid leukemia cells. Toxicol Res. 2010 Mar;26(1):21-8.
논문 31
Yin HQ, Choi YJ, Kim YC, Sohn DH, Ryu SY, Lee BH. Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration. Food Chem Toxicol. 2009 Jan;47(1):98-103.
논문 32
Li GY, Lee HY, Choi YJ, Lee MO, Shin HS, Kim HY, Lee SB, Lee BH. Changes in the Expression of Ras-family Genes in Rats Exposed to Formaldehyde by Inhalation. Toxicol Res. 2008 Sep;24(3):201-206.
논문 33
Yin HQ, Kim YS, Choi YJ, Kim YC, Sohn DH, Ryu SY, Lee BH. Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease. Arch Pharm Res. 2008 May;31(5):659-65.
